🧬 Dynamic RNA velocity model-- (5) global time normalization
scVelo source codes shows a ad-hoc voting method to calculate a global latent time, which was identified as key weaknees. Here present alternative methods to potentially address the relative scale of different genes and avoid the assumption of equal full cycle time for all genes.
May 28, 2025
🧬 Dynamic RNA velocity model-- (2) parameter inference
Here derives the mathematics underpinning the parameter inference of dynamic RNA velocity model, which is the second installment of our blog series to effectively apply the dynamic model in revealing the RNA velocity of single-cell RNAseq.
May 28, 2025
🧬 Dynamic RNA velocity model-- (1) math solutions
Here we delve into the mathematical foundations of the dynamic model of RNA velocity. This is the 1st installment of our blog series to clearly understand strengths and limitations of the dynamic model that is required for its effective application.
May 28, 2025