🧬 CCA reasoning and integration discussion
what is CCA really doing? here we dicepher it and present the mathmatical intuition to appreicate its applicability. Also, discuss the integration.
Apr 3, 2025
🧬 Clinical relevance evaluation in PRCC
I did not find any guidline to evaluate the Clinical relevance of mouse data. Here, I present my method used in the nature communications paper
Mar 31, 2025
🧬 Expressive cord diagram in PRCC
What could be expressive and concise presentation of cell-cell interaction? Here I write an small tool to draw Expressive cord diagram
Mar 30, 2025
🧬 Determine whether it’s noise or true stem like cells in PRCC
Sparse low number of cells belonging to cancer cell clusters exist in non-treated sample. Are they noise or artifact due to inperfection of integration algorithm or are they true stem like cells prediposted to be prone to tumorogenesis?
Mar 29, 2025
🧬 quantify xenograft and host gene expression from the same sample
Xenograft tumor is mixture of host cells and xenograft cells. Here I present the methode to simultaneously quantify the gene expression in both xenograft and the host cells.
Mar 28, 2025
🧬 counteract treatment-specific background in differential expressed gene analysis (huangcong paper)
The RNAseq dataset involves siRNA treatment, lentivirus infection and shRNA treatment. Here I present a way to formulate the generalized linear models to counteract treatment-specific background during differential expressed gene analysis
Mar 27, 2025